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In the pre-legal days, times were simple. You sent a text to a buddy, spoke in code and met in a weird place to pick up a small zip plastic
The post The Legal Troubles of Bob the Cannabis Farmer in the Legal Marketplace appeared first on Cannabis Kings .
In the pre-legal days, times were simple. You sent a text to a buddy, spoke in code and met in a weird place to pick up a small zip plastic baggie full of dry cannabis flowers. Yep. How simple it was. You didn’t give much thought to what you got. You just laughed at the funny name you could only guess and giggle at the origin of. White Castle is probably named that because somebody got the mad munchies and pigged out at the restaurant – you thought.
A question we all used to ask was I wonder how Bob is doing with his crop this year? We kept this question in our head, but all of us asked it even if your grower pal’s name wasn’t Bob.
A few months later, Bob’s crop was harvested, cured, trimmed and ready to go. It was perfect. Just what you had come to expect from a man with so much experience under his hoe.
You knew and trusted that Bob cared about his plants and he knew how to grow marijuana. Bob had fair prices too, 1 gram of weed would usually be 8-10$, cheaper than the meal you’re going out from after you had a smoke of his craft cannabis .
That’s how it went. If Bob didn’t get busted, he could theoretically do this full time for the rest of his life as a passion project, and a low overhead income so long as his property was well suited to outdoor growing.
In 2018, times changed. A version of what people wanted, a conditional Cannabis Act was signed into law. Some issues have come up for Bob with these new laws.
To grow marijuana legally, you now need a government issued license and hundreds of thousands of startup dollars to buy all the equipment government entities (most of which don’t know a thing about cannabis) tell Bob how he needs to start growing his plants if he doesn’t want to be charged as a criminal for being a part of the black market cannabis trade.
Bob can’t afford that. He’s a farmer, not a financial guru. So, he’s left with two choices. Go underground, or end his livelihood as he knows it and start looking for new sources of income, whatever they may be. Bob may have been a friend to some, but there’s no shortage of people who’ve frowned upon cannabis over the last several decades.
Stories like Bob’s are more common by the day. Large, government regulated indoor growing operations have started to take hold in order to fill a less educated consumer demand. Veteran growers like Bob, for the most part, couldn’t make the switch because of the laws that say they have to pay if they want to stay.
There’s a problem with that. If knowledgeable growers are forced out, we’ll lose medical diversity in the plants because large companies will get fixated on the consumer demand for more potent products.
Let’s face it, youth determine trends, and if the trend is high THC strains only, then the medicinal genetics of certain strains might vanish, and who knows what a succession of these vanishings could do for medicinal cannabis?
Like we said, Bob’s story is far from unique. Traditional craft growers like him and are being forced out right, left, and center. They can’t afford to bring their operations up to code, and if they want to keep growing without a license they can only keep 4 plants. To be fair that’s great for a single, but he wasn’t just doing this for himself.
We resonate with people like Bob and make small batch cannabis available, to support growers who decided to go the route of licensing themselves as small batch growers.
How does Bob’s story resonate with you? Let us know in the comments below.
Additional Resources
Cannabis Act Review: Medical Cannabis and Cannabis Health Products
Canadian Cannabis | Understanding Legal Cannabis Market Dynamics
Cannabis Act ( SC 2018, c. 16)
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You know those A ratings dotted around cannabis flowers? Those As represent the universally accepted cannabis quality ranking system that goes from A to AAAA+ ranking. This system has come
The post Street Tips for Cannabis Grades appeared first on Cannabis Kings .
You know those A ratings dotted around cannabis flowers? Those As represent the universally accepted cannabis quality ranking system that goes from A to AAAA+ ranking. This system has come into play thanks in large to the legalization of weed and may prove even more effective as a tool for the common consumer now that weed delivery is legal in Canada.
This system is a lot more sophisticated at first glance than one who’s still green to the cannabis industry might think. Some of the criteria measured are obvious: size, smell, color and effect – while others are less obvious: cannabinoid content, terpene levels and profile, strim, and cure.
With all this to keep in mind, how exactly do all these factors help us decide what grade cannabis flowers should be?
Here are a few key explanations of how the ranking system helps keep us in the know about the buds we love and the ones we might not.
Unless you lead with your nose, how a cannabis bud looks in a cannabis dispensary is your first good indicator of quality. As it turns out, the old saying – if it looks good it probably is – applies to cannabis pretty well.
The first thing you usually notice is the color and fuzzy texture. The brighter the green and accented colors like yellow, orange, purple, and sometimes even blue are, the more care was put into the plant it came from, hence the better the quality. For example, a bud like the one we just day dreamed about would likely be a AAA+ – AAAA+ based on how it looked alone.
The second thing to look for is trichome count. The more fuzzy and frosted a nug looks, the better it will be on the cannabinoid and terpene profiles. Make sure your trichomes are milky-clear in color. If they’ve turned amber, all you have there is baker’s weed. Amber means older trichomes, which mean they’ve lost most of their potency.
Something that correlates well with what we just talked about in trichome appearance is the smell of a cannabis bud. The reason is that the trichomes are the holy grail of the cannabis effect as they contain both the cannabinoids (THCA, CBDA), and all the different terpenes (beta myrcene, alpha-pinene, limonene, etc). The cannabinoids themselves are odorless, but the terpenes on the other hand, are responsible for ALL the scent and flavour profiles in the cannabis flowers. You can tell alot more than just grade from the smell of a flower, you can even predict the effects once you smoke it with a fair degree of accuracy.
Lemon smells usually mean uplifting, lavender type smells usually mean sedating and calming. This is a simplified explanation, but since we covered this in a previous post, we won’t got over it again here.
What you need to know for smell, is generally what you’d expect – the better it smells, the generally higher the quality.
This final metric builds on the last two so we chose to present it last. Growing conditions are probably the most important of any factor when it comes to cannabis quality. Seed and strain have nothing to do with how the final product is graded. THC content isn’t a primary factor either. No. What matters is how a plant was cultivated, first and foremost.
Grades are affected by how well a flower develops in relation to how it was cultivated and cured so if pesticides or growth chems or any malpractice was implemented, the grade would be equally affected. The higher the grade, the more pure and natural the crop was, and the safer it is to smoke too. Ever inhaled pesticides? With black market weed, you don’t have a definitive answer to that. Hence why we have regulations and grading systems in the legal markets.
For top quality cannabis of all grades, visit our store. Our curators know what they’re doing when they buy and sell cannabis online. This ensures you know exactly what you’re getting.
Pro tip, AA grade is generally better used to make edibles and butters, while AAA and up are best to be enjoyed smoked, or vaped.
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We know how you feel. There’s hundreds of strains to try out there, and there will be a healthy mix of ones you like, ones you don’t, and everything in
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We know how you feel. There’s hundreds of strains to try out there, and there will be a healthy mix of ones you like, ones you don’t, and everything in between. We carry nearly 50 cannabis strains in our inventory, and all of them are great, but we noticed a trend of popularity and attention forming around four particular strains of ours that we felt deserved investigating.
Here are four cannabis strains that have consistently ranked high in popularity, not just with our clients, but the cannabis industry as a whole.
Among the oldest and purest strains left in the world, Afghani Kush is a semi-domesticated pure indica strain that has a legacy worthy of its place in the modern market. Traditionally, Afghani Kush is from an area along the Afghanistan/Pakistan border and was used as the single ingredient to produce one of history’s most influential and high class products – Afghani Hash.
This ancestral strain of cannabis flower is one of the only elder cannabis plants in active cultivation today, making it a living link to cannabis history.
The experience with this strain is characterised by its earthy aroma and flavour, its high THC content, its myrcene dominant terpene profile, and its sedating effects.
The look of this bud is unmistakable as it features the dominant characteristics that have spawned its endless variations of sub-strains. With bright green flowers covered in vibrant orange hairs, it’s clear to see dominance of this ancestral strain’s genetics in most other cannabis on the market.
THC content: 16%
CBD content: <1%
Wedding Cake has been a smash hit since 2019 when leafly named Leafly Strain of the Year. A potent hybrid of Triangle Kush and Animal Mints, this cannabis flower takes the best qualities of its parent strains and blends them perfectly into a sweet and highly potent strain worthy of any party.
This strain is described by many as having a wonderful sweet aroma and flavour with hints of mint and lemon with a dazzling array of colors and a well frosted finish.
The effects reported with the popular bud include relaxation effects, feelings of happiness and contentment, and an increase in appetite. With a terpene profile dominant in limonene, this strain will help you feel relaxed, without robbing you of your ability to focus.
Advisory – this one sells fast so check often for restock.
THC content: 22%
CBD content: <1%
At a whopping 21% THC content, Bruce Banner will never get angry enough to go green. This popular strain has earned a special place in the hearts of cannabis lovers ever since it hit the market just a few short years ago. This strain is a cross between OG Kush (an Afghani Kush sub-strain), and Strawberry diesel – and given its popularity, it’s clear it took the best qualities of it’s two parent strains.
The look of this beauty can’t be appreciated enough as it features a vibrant green with purple leaves and bright orange hairs. This strain is known to have a sweet, earthy and diesel aroma and its amazing euphoria inducing effects. Because of it’s myrcene dominant terpene profile, you can be sure this strain will keep you well relaxed and unable to experience anger.
THC content – 22%
CBD content: <1%
Last but not least, the famous Girl Scout Cookies (GSC). This strain has become one of the most popular strains in North America, and for good reason. It checks off all the right boxes when it comes to the most common needs of cannabis users. It grants an energized high with a THC content of 19% and a caryophyllene dominant terpene profile that’s strong on the hit but does not rob you of your energy or focus. If we were to call the high anything, we’d say it was a cerebral and productive high.
This strain is a potent cross between OG Kush (an Afghani Kush sub-strain), and durban poison which has granted it with a sweet and buttery flavour profile. GCS, true to the name, gives off a dessert-like sweet and minty aroma which will always leave you wanting more. The buds themselves feature a vibrant color pallet of blues, purples, oranges, greens and yellows.
GCS has become so popular in fact, that growers have bred countless sub-strains to create all different kinds of variations on it’s signature profile.
THC content – 19%
CBD content: <1%
Summing up
We hope you enjoyed our top four list of in-house cannabis flower strains! Make sure to check our inventory so you can view our available strains and try them for yourself.
References
GSC aka Girl Scout Cookies Marijuana Strain Information
Bruce Banner aka Banner, OG Banner Marijuana Strain Information
Wedding Cake aka Triangle Mints #23 Marijuana Strain Information
Afghan Kush aka Afghani Kush Marijuana Strain Information
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Why are there so many marijuana names and quality ratings? Simple. Each strain has slightly different properties and is grown by different growers. That means the effects and quality vary
The post How to Strain Shop – Resources to Optimise Your Marijuana Experience appeared first on Cannabis Kings .
Why are there so many marijuana names and quality ratings? Simple. Each strain has slightly different properties and is grown by different growers. That means the effects and quality vary from strain to strain. To date, it’s estimated that there are several thousands of strains on the market, with that number growing daily as growers experiment with more and more hydriding combinations.
With that said, how do you know what kind of cannabis strains and grades are best for you?
We’ve decided to help you figure that out. Here are a few tips and tricks to help you pick your marijuana.
Recall past experiences with certain strains and research new ones
The first step in cannabis selection is to remember the experiences you’ve had with past strains you might already know (for the purposes of this example let’s assume you’re an experienced smoker).
For instance: “X strain caused X effect at this time of day/night and I felt good/bad about it.” That’s good data tobe able to identify what strains are good for you and which ones aren’t.
Research and sampling is the best way to build your knowledge base on cannabis. If you have limited experience and don’t know where to start, don’t worry. The next few tips will help regardless of your level of cannabis experience.
Strain – Sativa vs Indica
Technically, all stains on the market are sativas – yes, even indicas. Cannabis Sativa is the species name, and Indica is a subspecies of the parent Sativa species, which means all strains of cannabis on the market are all the same Sativa species. Think of cannabis like humans. We’re all the same species, and the only difference is adaptations to suit different environments. Cannabis works the same way. Over each generation, adapting itself to conditions and diversifying, but it still stays cannabis.
If we follow the accepted street terms of strain names – which will be more practical for research – sativas tend to be more associated with strong head highs, while indicas tend to be more of a sedating high. It’s hard to say if this is really the case or not however. Brains are all different, and so are strains of marijuanna. Even when passing a joint, most of us can easily tell we’re all reacting differently smoking the exact same joint. Best course of action here is to see how you’re feeling and if that’s what you wanted out of smoking at that moment. The effects listed online or in dispensaries are good guidelines as to what most people can expect, but nothing applies to everyone. Consider the information, then go with your flow.
Smell
The first great indicator of your projected experience is what the weed smells and tastes like, along with your reaction to it. If you feel good about what you’re smelling (happy, tingly, excited), then you’ve found your cannabis. If you’re not feeling as excited, it’s ok to keep looking around. In our last article , we briefly touched on some of the terpenes found in weed along with most other plants in various quantities that give plants many of their smells, tastes, and medicinal properties.
Here’s what we outlined about the 5 main cannabis terpenes:
Trichome Coloration
The color of the trichomes (small bulbous hairs that give cannabis its frosted color) are the next good indicator of what your experience may be. If you look at them closely, you’ll be able to notice if they’re clear, milky, or amber in coloration.
If they are clear, that means they’ll likely have a rich terpene profile with some cannabinoid content. Clear indicates younger trichomes that might not have yet reached full potency, but may still be potent and of good quality.
Milky colored trichomes are ones that have sufficiently matured to contain the full cannabinoid and terpene profile of the strains. Milky trichomes are what is most commonly found on the market.
Finally, amber colored trichomes are aged trichomes that have started to degrade and lose potency. Generally amber colorations are an indication of a loss of terpenes and low THC, high CBN (degraded THCA) content
Trim
We get it. You’re busting it up anyway, so why does trim matter? Well, it matters because of two reasons.
First, if you trim too close, you lose trichomes and compromise the flower. Shaved weed always means less potent, less aromatic weed.
Second, if you don’t trim enough, you end up with more excess plant matter and combustible material. That means it will be harder on your lungs even after fully cured.
Getting the right balance on the trim is an artisan process that machines have yet to master, so if you’re looking for quality, how the trim looks is just as important as anything else.
Cure
Curing quality is essential. If a bud is undercured, the amount of tar created while lighting the weed is much higher, and the burn isn’t clean or consistent. A visual queue for a bad cure is the color of the smoke and ash. If the smoke is a darker grey and the ash is jet black, then the bud still has too much moisture content. Moisture also means the potential for mold, so be cautious if you suspect improper curing.
It’s also possible to overcure a bud. If a bud is too dry, most of the terpenes will have evaporated off, leaving you with little more than a dry cough and a mild high.
The A-AAAA+ Scale
With all of the above now considered, the A-AAAA+ scale is a ranking system that the industry uses to rate marijuana flowers based on factors which include the ones already outlined.
A-AA are best used for making extracts and edibles since they tend to be a lower quality in all the above categories.
AAA quality is the general industry average for commercial crop, so when making a choice, aim at least for that grade or better.
AAAA+ is typical of small batch artisan grown weed that’s been carefully grown in the best conditions with the processing being more of an artform.
Strain Names
If you search on leafly, you’ll probably never run out of strains to read up on. It can be a bit overwhelming trying to find something to fit a need you might have while using names alone as your deciding factor. Whenever you pick a strain, read what the aroma and flavour profiles are, and what the THC/CBD contents are.
The way a bud smells and tastes will tell you what terpenes are likely in it and the THC/CBD ratio. Both will give you clues on what that marijuana strain could be good for. If you get anxious about smoking, then go for a low THC, high CBD strain. If you need help sleeping and with concentration, go midlevel THC content. If you’re looking for crazy nacho parties with friends, go for a high THC strain.
Remember that the names are important, but descriptions, ratings, smell, tastes and feeling are more important. Don’t shy away from a little extra work. In the end, it’s worth it.
References
– EPISODE #80 Interviewing the Godfather of Cannabis Research – Prof. Raphael Mechoulam
-How to Judge Cannabis as a Connoisseur: Casey O’Neill / Green Flower- https://www.youtube.com/watch?v=FG99WAti6IU
-The www.revealcannabis.com Top 5 Terpene Reference Chart
-The Little Black Book of Marijuana, by Steve Elliott (2017)
– Explore marijuana strains for 4/20 – leafly.ca
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In 2003, Chinese pharmacist Hon Lik was looking for a way to quit smoking that didn’t involve the need for slow release nicotine patches. In time, his quest led him
The post Vaping – The Basics on the Lung Saver appeared first on Cannabis Kings .
In 2003, Chinese pharmacist Hon Lik was looking for a way to quit smoking that didn’t involve the need for slow release nicotine patches. In time, his quest led him to create the first ever commercially available electronic vaping device – the Ruyan e-cigarette.
The Ruyan device was the first of its kind to make use of vape juices, delivering the same concentrations of nicotine into the system at the same speed as a traditional cigarette, without the vast majority of the other 6,000 chemicals and tare residue. Once this fact became known, more and more cigarette smokers made the switch to juices to reduce the health risks of traditional smoking, and it was only a matter of time before the legal cannabis industry followed suit in both Europe and North America.
On October 17th, 2018, The Cannabis Act officially became law in Canada, which marked the first time in nearly 100 years that recreational cannabis could be legally consumed without the need for a medical diagnosis. One year later, on October 17th, 2019, the law was amended to bring cannabis vaping products under the wing of federal regulations, making the product reliability and safety standards we know today an industry standard, on par but separate from, the strict regulations of nicotine vaping products under The Tobacco Act.
Prior to the amended 2019 laws, vaping products containing cannabis were mostly a black market trend that came with certain risks and considerations.
Thankfully, the dark ages of black market cannabis vaping are largely behind us and vaping has become a staple in modern cannabis culture.
It’s been so successful in fact, that many traditional dooby die-hards are making the switch because it’s much cleaner and customizable than combustion based methods like joints, bongs, pipes and others. If you’ve ever had to clean any of those glass or metal devices you know what we mean by a cleaner high.
Vaping has taken 2 different routes that have caused clouds of interest to form around them – dry herb vaping, and juicing (juice vaping).
Each of these methods share the majority of basic properties, but have a few notable differences between them.
Dry herb vaping
Dry herb vaping is a new twist on the traditional method of smoking cannabis flower. Instead of combusting the flower with a flame in excess of 450 degrees, which burns away the fragil terpenes of cannabis flower, you instead select a temperature that best suits the extraction of the desired effects from your cannabis dry flower.
This works by using hot air to heat the cannabis flower to a set temperature as not to ignite it but to trigger the evaporation of the terpenes and also dearboxilate the THCA into the non-acidic psychoactive THC.
Different effects can be produced from the same dried flower depending on the temperature setting because different terpenes have a different evaporation temperature.
Here are some examples of boiling points for extraction:
With this kind of extraction control available in dry herb vaping, you can truly make your cannabis experience your own.
As a bonus, because plant matter is not burned off, a good level of THC and other cannabinoids are still locked in the leftover plant matter after it’s been vaped. What can you do with it? Make butter of course!
Juicing (Juice Vaping)
Juice vaping is just as clean and optionally temperature controlled as dry herb vaping (depending on your device’s capabilities), but that’s where the similarities end. Unlike dry herb vaping, juicing is an extract based form of vaping that uses concentrated, and carefully crafted vape juices that come in an almost endless array of variations.
Everything from the terpene profile, to the extracted strain, to the flavours, to the cannabinoid concentrations, can all be precisely controlled in the manufacturing process ensuring a fully customisable cannabis vaping experience.
All the rules of dry vaping when it comes to the evaporation of terpese still apply, but in this case they’re suspended in a water based liquid that’s heated with a coil in order to boil off the juice at the desired temperature, making it possible to vape it.
Unlike dry herb vaping, juicing doesn’t have any leftovers, which can make for an easier cleanup if saving dry herb doesn’t appeal to you.
Summing up
In terms of smoking cannabis, vaping is still a fairly new and sometimes misunderstood smoking strategy due to having started in the cannabis black market before it was regulated by the Canadian government in 2019. But rest assured, the science is in. Vaping is indeed much safer for your lungs than traditional forms of combustion smoking (joints, bongs, pipes, etc) because it doesn’t involve inhaling burning plant matter that carries with it tar and other burning carcinogens.
We hope your new knowledge of how vaping works can both wow your friends and help keep them healthy and happy stoners for years to come!
Before you go, check out our selection of vape products by visiting our store here!
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When we think of cannabis medicine, many would think of the standard ways of smoking it as the primary means of benefiting from it. Although common, this is a narrow
The post Cannabis Medicine – How to boost cannabinoid bioavailability from CBD isolate appeared first on Cannabis Kings .
When we think of cannabis medicine, many would think of the standard ways of smoking it as the primary means of benefiting from it. Although common, this is a narrow avenue that covers only a small percentage of the potential medical uses for cannabis.
With all the different products on the market, each with their own distinct forms of application and/or consumption, the ways in which we can use cannabis as a remedy has exploded in recent decades.
But which products do what, and how best do we use them?
This article will focus on cannabis CBD isolate and how to best use it to create a homemade tincture, and how to also boost the effectiveness of topicals to potentially help with various muscle and joint conditions.
What is CBD isolate (crystalline)?
CBD isolate is an incredibly dynamic product with an almost unlimited range of potential therapeutic applications. An isolate can be as pure as 99% CBD crystalline (powder-like CBD crystals), with less than 0.2% traces of THC or any other cannabinoid or terpene, or plant matter.
As is commonly known, CBD has potent anti-inflammatory and neuro-modulating properties that can be beneficial either topically, orally, or even smoked. What is less known however is which form of consumption is best for which targeted condition, and even less known by the general public on bioavailability.
CBD isolate (crystalline) for tinctures
Depending on how you want to use a CBD isolate, your options are quite diverse. Here are some tips you can use to help make the most of your isolation powder when making a homemade tincture.
Cannabinoids (CBD, THC, THCA, CBDA, CBG, etc..) are fat soluble molecules. If you’re planning to make a homemade tincture, it’s important to use a healthy, fatty oil like avocado or MCT to blend your isolate into, rather than filtered water. Clinical recommendations for this preparation range are between 10mg-40mg of CBD isolate for every 1ml serving. Fish oil is the best oil to use because of the omega-3 content (omega 3 is a foundational neuro-transmitter fatty acid), but some may not like the taste. Omega-3 fatty acids are highly binding to both cannabinoids and neural receptors in the body which dramatically increase bioavailability into the upper 30%+ ranges, versus the 6-9% ingestion baseline.
The added bioavailability also means you can use less of your isolate and get better results.
The reason for this is that CBD is difficult to absorb in the digestive system since it’s broken down faster than it can be metabolised. Tinctures made with fatty oils and left under the tongue to be absorbed for 30-60 seconds by the mucosal and salivary glands is the fastest way to get a high amount of CBD into the bloodstream as quickly as possible if smoking or vaping high CBD cannabis is not an option.
This delivery system for CBD isolate is the primary way sudden onsets of seizures and seizure prevention can be quickly and easily administered when needed since there is no need to involve the act of swallowing or smoking something – which could be dangerous for someone who has lost some degree of motor function.
CBD isolate (crystalline) for topicals
The bioavailability problem doesn’t just apply to oral applications, but topical ones as well. The ratio of absorption of CBD topically is roughly the same as it is for nonfat bound oral (6-9%), no matter what the concentrations may be.
The good news is, you can help the absorption rate of topicals as well. The secret for topicals lies in using both fatty oil binding techniques similar to tinctures, but with an added twist – rubbing alcohol.
Alcohol is effective at helping boost CBD’s topical benefits because it helps open up the skin by boosting the skin’s transdermal permeability at the site of application – meaning the skin can more readily absorb anything that is in contact with the alcohol.
Caution should be used with this tip however, as anything on the application site will be more readily absorbed into the skin thanks to the alcohol.
We don’t recommend mixing the alcohol with your topical CBD as this could break it down if it’s being stored. If you’re looking to boost topical CBD absorption, rub a bit of rubbing alcohol on the application site first, then apply your CBD topical and an oil like MCT to help it absorb further.
Tip to slow CBD degradation
Always ensure CBD products, homemade or otherwise, are stored in dark cool areas. Light and heat both represent elevated levels of molecular energy – meaning CBD particles will vibrate themselves apart more quickly and degrade if stored improperly.
Where to buy CBD isolate
Cannabis Kings has you covered. Visit our store here , and purchase our 99%+ pure CBD crystalline isolate and experiment with uses that best suit you.
References
A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray – Stott CG, White L, Wright S, Wilbraham D, Guy GW. A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray. Eur J Clin Pharmacol. 2013 Apr;69(4):825-34. doi: 10.1007/s00228-012-1393-4. Epub 2012 Oct 4. PMID: 23052407.
Molecular Targets of Cannabidiol in Neurological Disorders – Ibeas Bih C, Chen T, Nunn AV, Bazelot M, Dallas M, Whalley BJ. Molecular Targets of Cannabidiol in Neurological Disorders. Neurotherapeutics. 2015 Oct;12(4):699-730. doi: 10.1007/s13311-015-0377-3. PMID: 26264914; PMCID: PMC4604182.
How To Increase CBD Bioavailability – Evopure (2020)
How to Increase The Bioavailability of CBD – Cannabidiol360 (2018)
Therapeutic impact of CBD & Full Spectrum Cannabinoids | Fullscript Webinar – Fullscript (2020)
Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity – J Occup Med Toxicol. 2008; 3: 26.
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Anatomy of glandular trichomes If you’ve ever seen a flower, odds are that you’ve also seen trichomes – more accurately called glandular trichomes – without even noticing them. Glandular trichomes
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Anatomy of glandular trichomes
If you’ve ever seen a flower, odds are that you’ve also seen trichomes – more accurately called glandular trichomes – without even noticing them. Glandular trichomes are present in approximately 70% of all flowering plant species all around the world and perform a variety of key functions to aid in a plants ability to communicate, as well as survive. The compounds act as insecticides, pollinator attractors, aromatics, and communication chemicals so that plants can communicate with each other as well as their environment.
The reason you might miss trichomes in the wild is that they are typically very small in size. So small in fact that they are measured in µm (micrometers), but on cannabis plants, glandular trichomes can be seen by the naked eye. The reason for this is generations of selective breeding strains of cannabis, over countless generations, to select genetic traits in the cannabis plants for larger glandular trichome structures.
Why selection for larger glandular trichomes is favored among cannabis growers, is a result of a happy accident of biochemistry that enabled humans and cannabis plants to form a symbiotic relationship. The cannabinoids the plants produce are able to modulate our own endocannabinoid systems via a type of “lock and key” interaction where certain cannabinoids in the cannabis plant match closely enough to our own endocannabinoids as to be able to fit and modulate the CB1 and CB2 receptors in our bodies.
There are multiple types of cell structures that make up a glandular trichome. These cell include: epidermal cells which make up the stem’s exterior (skin), hypodermal cells which make up the stem’s interior, basal cells which make up part of the excretion tip, stripe cells which are the mid-point cells of the excretion tip, secretory cells which are the cells that excrete all of the fluid.
Glandular trichomes on a plant are similar to hormon and sweat glands in animals in several ways. They both produce scents, chemical compounds, lipid molecules and various other excretions vital in the most basic of biological processes. Where plants and animals differ however is the chemicals those glands produce.
As far as cannabis and other flowering plants are concerned, they produce: terpenes, terpenoids, phytochemicals and cannabinoids – which is why breeders of cannabis plants have selectively bred larger and larger structures for so many successive generations.
The governing of cannabis properties and effects
In cannabis plants, there are three different types of glandular trichome structures: bulbous, capitate sessile, and capitate-stalked. The cellular structures – as mentioned above – of these three types do not change, the types are simply names that are given to different shapes and yields of glandular trichomes. Cannabis plants, particularly marijuana females, have larger trichomes than male hemp plants as well as having them in greater numbers. This is the factor that makes THC more abundant in marijuana plants than in hemp plants. Contrary to popular belief however, hemp plants do indeed contain THC in minute concentrations of approximately <0.035%. Any higher and the plant can no longer legally be called hemp.
As a glandular trichome forms and ages it begins to fill with clear fluid that over time becomes cloudy as the concentrations of terpenes, terpenoids, cannabinoids and phytochemicals start to increase. The exact ratios of these compounds is what is used as the primary means of identifying a cannabis strain.
If a plant reaches advanced maturity before it is harvested by a grower, the fluids on the tips of the glandular trichomes turn to an amber color, burst, and release all the contents of the tip of the glandular trichome. This signals the environment announcing the plant’s defence mechanisms, reproductive potential, edibility and pollination potential. But overall, it is a marijuana plant’s last ditch effort to reproduce before the end of the season.
Over generations, cannabis growers have learned to influence ratios of the compounds found in cannabis plants by altering growing conditions and inducing or reducing the stresses on a plant. For example, UV light increases terpene production and increases the expression of terpene producing genes. Although this does not alter the overall parameters of the strain being cultivated, it can increase or decrease the potency of the flower in the end product, depending on how much UV light the grower exposes the plant to.
Through the selected breeding methods outlined above and the alterations of growing conditions such as: UV exposure times, temperature, soil composition and watering frequency, growers have managed to produce approximately 1024 genetic possibilities for cannabis plants each with their own unique balance of medicinal properties.
Summary
Who would have guessed that such small structures could determine such a strong symbiosis between cannabis and humans. Through countless generations of selective growing combined with the already fascinating properties of hemp and marijuana, growers across time have managed to give us a plant that holds medicinal value so vast we have yet to figure out how to make full use of it.
There are ongoing studies that are looking into how different cannabinoid and terpenoid profiles can be tailored as targeted medicines for the specific needs of individuals with wide ranges of conditions.
Many years of research lie ahead, but rest assure that glandular trichomes will remain as the stars of the majority of the discoveries still to come. Remember to stop by our shop and order some flowers! Once you do, get your hands on a magnifying glass and take a look at glandular trichomes up close. Would you be able to identify them by one of the 3 types?
References
Cannabinoids, Terpenes & Trichomes Webinar , Presented by Carlos Jose Angel Hermida, M.B.A,, Hosted by Florida Cannabis Coalition, 2017
What are trichomes? | Cannabis Glossary , Leafy, 2021
Controlling Terpenes and Cannabinoids in Flower and Extract Presented At Cannabis Sciences Virtual Event 2018, Presented By Markus Roggen, PhD VP Extraction, OutCo
Size and morphology of leaf trichomes.A) Stalk and branch length of… – TY – JOUR
AU – Ojangu, Eve-Ly
AU – Tanner, Krista
AU – Pata, Pille
AU – Järve, Kristel
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AU – Paves, Heiti
PY – 2012/06/06
SP – 81
T1 – Myosins XI-K, XI-1, and XI-2 are required for development of pavement cells, trichomes, and stigmatic papillae in Arabidopsis
VL – 12
DO – 10.1186/1471-2229-12-81
JO – BMC plant biology
https://pubmed.ncbi.nlm.nih.gov/16024552/ – Sirikantaramas S, Taura F, Tanaka Y, Ishikawa Y, Morimoto S, Shoyama Y. Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomes. Plant Cell Physiol. 2005 Sep;46(9):1578-82. doi: 10.1093/pcp/pci166. Epub 2005 Jul 15. PMID: 16024552.
Hércules Rezende Freitas, Alinny Rosendo Isaac, Renato Malcher-Lopes, Bruno Lourenço Diaz, Isis Hara Trevenzoli & Ricardo Augusto De Melo Reis (2018) Polyunsaturated fatty acids and endocannabinoids in health and disease, Nutritional Neuroscience, 21:10, 695-714, DOI: 10.1080/1028415X.2017.1347373
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The endocannabinoid system is one of the most important and ingrained systems in the animal kingdom. Is it present in all animals, except insects, and governs the function of every
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The endocannabinoid system is one of the most important and ingrained systems in the animal kingdom. Is it present in all animals, except insects, and governs the function of every other system in the body. But what is it exactly? How did we discover it? How does it work?
In this article we’d like to help answer those questions for you.
The Discovery of the Endocannabinoid System
Contrary to what you might expect, the endocannabinoid system was not discovered before cannabinoids or the receptors. It was discovered much later than that. 20-25 years later to be exact. What came first was the isolation and discovery of Delta-9 THC in 1969 in Israel, followed by the discovery of endocannabinoid receptors CB1 and CB2 between 1988,1990, and finally the system as a whole was identified in 1993. This subsequently led to the discovery of the endocannabinoid system as being a dominant regulatory system present throughout the body.
How dominant is it?
It governs everything. The system is present in every system and cell in the body, right down to the synaptic level and within every cell’s mitochondria. According to Dr. Rachel Knox, an expert on this system as well as a TED speaker, any disease that can be diagnosed including allergies, cancers, cognitive dysfunctions, organ issues, skin issues and even personality disorders can be traced directly to dysfunctions of the endocannabinoid system. The discovery of this system and the ongoing work to decode it could lead to breakthrough therapies for a multitude of dysfunctions and diseases in the near future – something the legal cannabis market will likely play a large role in facilitating.
CB1 and CB2 Receptors
Within the endocannabinoid system, there have been two different kinds of receptors, each with their own specialised functions – the CB1, and CB2 receptors. CB1 the main receptor that controls the central nervous system and homeostasis. CB2 modulates the peripheral nervous system, inflammatory response, immune responses and pain responses.
CB1 Brief Overview
CB1 receptors are what allow us to get high from THC, and are the primary flow valves that control our cognition and central nervous system. Their function can be enhanced and/or stimulated by taking DHA supplements because endocannabinoids are a fat-based lipid molecule. THC is a CB1 agonist, meaning it acts on the CB1 receptor, widening or contracting it, causing effects on the central nervous system as well as enabling the psychoactive properties of THC. But THC’s interactions with CB1 aren’t just psychoactive in nature. THC is currently being studied to have positive effects, in individual specific measured doses, to help control gut based diseases such as crohn’s and celiac disease. The proper function and preservation of CB1 receptors is also vital to sustain long term general and cognitive health as well as help prevent neuro-degenerative disease. THC and other cannabinoids found in cannabis plants are currently being studied for their neuro-protective properties in terms of how they interact with CB1, and how they can slow or even prevent some diseases from progressing – thanks to CB1’s modulation of the central nervous system.
CB2 Overview
CB2 is the receptor responsible for the effects of CBD and it’s soothing properties. It is theorised that as animals became more and more biologically complex at some point a mutation of CB1, over countless generations, evolved to take on more specialized functions such as immune regulation, inflammation regulation, and pain regulation. In that process, eventually that mutated CB1 became its own dedicated receptor – CB2. Because of this inflammatory regulation role, CBD can fit this receptor and help modulate inflammation throughout the body – most notably in the digestive tract and vital organs.
Studies are currently underway to determine if CB2 dysfunction may be a factor in inflammatory brain diseases such as epilepsy, which could prove to be the source of CBD’s positive effects on the treatments of seizures and severe neurological disorders in both adults and children. Because THC doesn’t need to be present in CB2 based treatments, this could eventually lead to clinical prescriptions of CBD based treatments that could be used over a wide variety of conditions in multiple age categories. Much more research is needed, but ongoing studies are yielding promising results in both adults and children for both epileptic disorders and other neurological illnesses such Parkinson’s disease and others.
The Possible Future of Cannabis Medicine
More research is needed, but so far the results over the last 25 years have been quite promising for clinically prescribed cannabis to have a future role in disease treatment prevention – maybe even to change its status from drug to that of an essential nutrient. There is sufficient evidence to support that cannabis has been a medicine in multiple cultures across time all around the world as far back as 1st century China, maybe even sooner. Cannabis prohibition didn’t enter the picture in western culture until the late 1920s to early 1930s. Before then, cannabis tinctures, cannabis oils, cannabis topicals, edibles, and joints were not only widely used but accepted as valid medicines to treat a staggering array of ailments.
Today, we’re slowly moving back to the glory days of legal cannabis medicines on the back of mounting clinical evidence for what we’ve seemed to understand via observations of cause/effect since antiquity. It is unlikely that we will regress back into the dark ages of cannabis fear campaigns, but the progress will remain slow as public perceptions on any subject tend to shift slowly generation by generation, not year by year.
Summing up
The endocannabinoid system is a fascinating one with almost unlimited potential for study and discovery. We are only beginning to scratch the surface on what secrets the system and CB receptors have in store for us, not to mention the discoveries that await us in terms of how the cannabis plant can help modulate them.
As time goes on, we will undoubtedly see new applications in cannabis based medicine and refinements on how we could potentially use different cannabis strains as legitimate medicines for specific conditions.
We hope you’re as excited as we are about the future of cannabis medicine!
Don’t forget to come by our online shop to have a look at our product selection and use the knowledge you’ve just gained to help you pick out the best products to fit your needs.
Happy shopping!
References
EPISODE #54 The Endocannabinoid System with Dr. Rachel Knox, Endocannabinologist & Certified Cannab
Witkamp R. Fatty acids, endocannabinoids and inflammation. Eur J Pharmacol. 2016 Aug 15;785:96-107. doi: 10.1016/j.ejphar.2015.08.051. Epub 2015 Aug 29. PMID: 26325095. – Fatty acids, endocannabinoids and inflammation
Katchan V, David P, Shoenfeld Y. Cannabinoids and autoimmune diseases: A systematic review. Autoimmun Rev. 2016 Jun;15(6):513-28. doi: 10.1016/j.autrev.2016.02.008. Epub 2016 Feb 11. PMID: 26876387. Cannabinoids and autoimmune diseases: A systematic review
Wiki – Cannabinoid receptor type 2
Wiki – Cannabinoid receptor type 1
Sharkey KA, Wiley JW. The Role of the Endocannabinoid System in the Brain-Gut Axis. Gastroenterology. 2016 Aug;151(2):252-66. doi: 10.1053/j.gastro.2016.04.015. Epub 2016 Apr 29. PMID: 27133395; PMCID: PMC4961581. The Role of the Endocannabinoid System in the Brain-Gut Axis
Fasinu PS, Phillips S, ElSohly MA, Walker LA. Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents. Pharmacotherapy. 2016 Jul;36(7):781-96. doi: 10.1002/phar.1780. PMID: 27285147. Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agent
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Terpenes and terpenoids play a vital role in the health and wellbeing of plants as a whole. They’re produced by plants – not for an animal’s benefit, but for their
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Terpenes and terpenoids play a vital role in the health and wellbeing of plants as a whole. They’re produced by plants – not for an animal’s benefit, but for their own – in order to communicate with one another, to stop certain animals and insects from eating them, and serve as communication molecules to signal other plants, as well as attract pollinators such as bees.
The difference between terpenes and terpenoids is that terpenes are often made only of carbon and hydrogen, while terpenoids on the other hand incorporate other molecules, of the most common being oxygen, into their molecular structure.
Terpenes and terpenoids can be one of three different molecular structures: acyclic, monocyclic and polycyclic.
Acyclic means the molecule has no carbon rings in its structure, monocyclic means it has one carbon ring, and polycyclic means it has more than one carbon ring.
There are between 20,000-30,000 named terpenes and terpenoids in the plant world that have so far been discovered, of which over 200+ can be found in cannabis – making it the plant with the richest terpene profile known to science.
In order to help you pick what kind of weed to buy based on what your wants or needs might be, we’ve decided to pick 5 terpenes found in cannabis you’ll likely be familiar with and describe how they work within the body. We’re hoping this will help you narrow down your shopping list with us and get you the right bud!
Myrcene
This monoterpene is found all throughout nature in plants such as hops, mangos, bay leaves and a large array of other spices and herbs like thyme and parsley. Myrcene is the dominant terpene in modern cannabis strains, although that was not always the case. Market trends have dictated a higher demand for “couch lock” weed strains and since myrcene is responsible for “couch lock” – even more so than high CBD – it is believed to have strong sedative effects in elevated doses. High myrcene strains remained relatively uncommon until recent decades as the demand for highly sedating weed has suddenly skyrocketed. Before then, a different terpene, beta-caryophyllene,t was the dominant one found in cultivated cannabis.
Myrcene helps with pain, mood, muscle spasms, sleep and relaxation.
Strains we carry high in myrcene include Venom OG , Bruce Banner , and UK Cheese
Limonene
Limonene, a citrus terpene, is a compound found commonly in nature. So much so that it is the second most common terpene found in the wild. It’s found in citrus, lemon grass, dill, chives, and hundreds of other plants. There are many subtypes of Limonene. For example, D-Limonene is the terpene found in citrus fruits.
Limonene is an uplifting and relaxing terpene. When we inhale limonene, we feel a heightened sense of internal awareness and calm. When you smell an essential oil containing limonene, or a cleaning product, or a tea – you feel soothed, relaxed, and centered. The reason for this relaxation is Limonene.
Limonene’s effects include: reducing anxiety, helping stabilize mood, reducing the symptoms of depression, and to aid with sleep by reducing stress levels in the body.
Strains we carry high in limonene include: Black Mamba and El Jefe .
Alpha-Pinene
Alpha-Pinene is much less common in modern commercial cannabis plants, but is the most common terpene in nature overall. Selective breeding and consumer trends had selected this terpene out in the majority of cultivated cannabis, although some growers still produce strains with more traditional amounts of alpha-pinene. Alpha-pinene is primarily found in pine trees, conifers, rosemary, and eucalyptus, and sage. topical oils we use to treat skin irritations, abrasions, and muscle complaints.
Alpha-Pinene’s effects are in stimulation rather than sedation and relaxation. It helps with focus, energy, and helps counteract the effects of THC induced memory loss by inhibiting the breakdown of the memory molecule acedocoleine.
Linalool
A floral terpene, Linalool is another common terpene in nature. Purple plants typically have linalool as their dominant produced terpene although there are some exceptions to this such as birch trees, citrus, and coriander – which are all high in linalool yet are not purple colored.
Linalool is known for its sedative and relaxing effects, its anti-inflammatory effects, and is also a powerful anti-convulsive. Cannabis strains which are naturally higher in linalool may be best used to extract cannabis oils for medical uses because of these relaxing and anticonvulsant effects. For it’s relaxing and anti-inflammatory effects, it is commonly used in body washes and soaps.
Purple strains, mostly indicas and indica dominant hybrids, are high in linalool.
Beta-Caryophyllene
We saved the most interesting terpene for last. Beta-caryophyllene is a terpene, as well as a cannabinoid. How is that possible? Cannabinoids and Terpenes are both produced in the trichomes of the cannabis plant which are most abundant in the unfertilized female plant’s top flower structures. Beta-caryophyllene is the second most common terpene in cannabis as a result of this dual status. Aside from cannabis, peppers, licorice, peppercorn, oregano, clove, cinnamon and other such spices are all high in b-caryophyllene.
Known effects of this terpene are: anti-inflammatory effects, antimicrobial effects, gastrointestinal pain relief, and general pain relief. The reason for these effects is due to the dual status as a cannabinoid. Because of the molecular structure, beta-caryophyllene binds to the CB2 receptors of the body’s endocannabinoid system. CB2 receptors are the same receptors responsible for the medical benefits of CBD.
A strain we carry high in beta-caryophyllene is Peanut-Butter x Banana , Purple Space Cookies , and Banana Split
Bonus Info – The Entourage Effect
The Entourage Effects is a term used to describe the synergy of compounds such as different terpenes and cannabinoids for promoting optimal health through having all the compounds working together. Cannabis plants each have distinct terpene and cannabinoid profiles comprising hundreds of compounds present which are present throughout the plant. Isolates, although effective, are possibly not as effective as multiple compounds being used together. Further research is needed, but the theory is interesting nonetheless.
We hope you enjoyed this educational article on terpenes! Remember to check out the strains mentioned to see which is right for you!
References
Terpenes & Terpenoids | Presented by Dr. Jamie Corroon
Cannabis Terpene Alpha Pinene | Effects, Research & More
Cannabis Terpene Linalool | Effects, Research & More
Cannabis Terpene Beta Caryophyllene | Effects, Research & More
Cannabis Terpene Limonene | Effects, Research & More
Cannabis Terpene Myrcene | Effects, Research & More
Top 5 Terpene Reference Chart, by Andrea Meharg, 2018, www.revealcannabis.com
Controlling Terpenes and Cannabinoids in Flower and Extract
Terpenes in Marijuana – Explained by Dr Jake Felice
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As any cannabis enthusiast will tell you, virtually nothing about smoking or using some sort of cannabis based product is done universally or for the same reasons. Everyone has a
The post 3 Uncommon But Interesting New Cannabis Products appeared first on Cannabis Kings .
As any cannabis enthusiast will tell you, virtually nothing about smoking or using some sort of cannabis based product is done universally or for the same reasons.
Everyone has a specific preference, need, routine, and goal when it comes to how they select a product that’s right for them. And there are LOTS of different products and variations of products on the market today that give people a virtually endless selection of desired cannabis experiences.
That being said, are there any particular cannabis based products that are worth mentioning more than others because they fall into unique categories such as how they’re used and why?
We think there are.
Before we give you our list, it’s important to state that individuals all have preferences, likes and dislikes of any particular product so this list is far from universal. What this list is intended for is to help you see what might be on the market that you might not have heard of before. Or, if you have, to know if you should give it a try having learned a little more about it.
So with that in mind, let’s get started!
Here are 3 cannabis products on the market today that we think everyone should know about.
Terp Sauce is fairly new to the extracts marketplace. It’s made by extracting trichomes from freeze dried cannabis plants with a butane solvent process, then left in a sealed jar for several weeks in a warm dark room or storage area. Over time, cannabinoids form crystals in the bottom of the sauce and slowly separate from the terpenes. The crystals at the bottom are highly concentrated cannabinoids, with the primary one being THC-A, the pre-courser acidic form of THC.
As you may have guessed Terp Sauce is primarily composed of terpenes, of which the ratios will depend entirely on the flower from the strain the sauce was extracted from. Different strains will produce different sauces that each have different medicinal properties depending on the dominant terpenes of the flower.
For example, an extract made from pink kush would leave you with a terp sauce high in myrcene, which would be sedative in nature. A sauce made from pineapple express would produce a terp sauce high in caryophyllene, which would be better for inflammation control and pain relief.
In terms of how to consume terp sauce, you can either dab it, or vape it. Vaping would be the most effective means to consume terp sauce since you could control the activation of which terpenes you want based on adjusting the temperature of the vaporizer.
This extract is pretty straightforward in that the name really says it all. CBD isolate is a 99% isolated CBD compound in powdered crystal form. Unlike braude spectrum and full spectrum products, CBD isolate does not contain any THC or other cannabinoids or flavonoids. It’s as pure as pure gets.
The process to extract CBD crystals is nearly identical to isolating THC or any other compound so for that reason we won’t go into detail on how it is extracted, but what we will talk about is the difference between isolated CBD and broad, and full spectrum CBD.
CBD binds to the CB2 receptor in the body’s endocannabinoid system which is the system responsible for inflammatory and immune signaling responses. Because it binds so well, it can help modulate immune responses and suppress excess inflammation.
One drawback of isolates in general – not just CBD isolates – however is that they do not contain any other of the beneficial terpenes, flavonoids or cannabinoids. As mentioned in the introduction, this is neither a good nor a bad thing. If a high CBD concentration product is best for you for factors such as not wanting to get high or maybe a terpene sensitivity, then powdered isolate may be the way to go for you. The best ways to take isolates such as powders is either diluted in a beverage, or combined with an oil and used topically.
CBD vape pens are not much different to standard vape pens. The difference is what they’re designed to burn. Like THC pens, CBD pen cartridges don’t actually contain any oils. They’re made from extracted “juices” that are primarily extracted with solvents such as butane, then combined with some food based ingredients that are known to be safe to inhale, producing most commonly either a full-spectrum or broad-spectrum vape “juice”. Oils themselves like MCT for example, are NOT safe for burning and inhalation. The reason is the residue can bind to your alveoli in your lungs and cause significantly increased risk for lipid based lung infections and lipid based pneumonia, which is why the term “vape oil cartridge” or similar ones are generally misleading.
Why use a CBD vape versus an oral oil? Well, the evidence is not exactly clear, but the general accepted theory so far is that CBD vape pens tend to have a much faster uptake into the bloodstream, allowing them to begin to work much more quickly than an oral drop.
But like inhalation vs ingestion of THC, the effects may be stronger initially, but may not last as long. More research into this is needed, but for the moment CBD vaping seems a legitimate means of getting the effects of CBD directly into the bloodstream as fast as possible, which could have a wide range of medical applications that would require rapid administration.
We hope you enjoyed this informative look into less common but well worth checking out cannabis products that are available on the market! Don’t forget to check out our shop and browse our selection!
References
Concentrates. What’s The Difference? Erik Khan, 2020 – https://www.youtube.com/watch?v=Ds88T5phyTs
Reviewed by Lesley Nickus on 3/15/21 – What are cannabis concentrates and how do you consume them?
CBD Isolate: Uses, Effects and Benefits, Medical News Today – CBD isolate: Uses, effects, and benefits
Healthline, Medical Review, 2018 – Lung Anatomy, Function, and Diagrams
Cannabis Cannabinoid Res. 2018; 3(1): 152–161.
Published online 2018 Jul 1. doi: 10.1089/can.2018.0006, Jamie Corroon, and Joy A. Phillips –
A Cross-Sectional Study of Cannabidiol Users
Vaping 360, Things You Need to Know Before Vaping CBD Oil by Dave Kriegel
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